PROVEN CLINICAL EVIDENCE 

Syn®-Ake (Tripepetide)   Winner of Swiss Technology Award 2006 Clinically proven to reduce wrinkles by 52% in 28 days and 82% Smoothing effect giving our clients this effective, painless, Age Killing Ingredient.

 

Syn®-Ake (Tripeptide) is an anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, found in the venom of the Temple Viper Snake. The biological activity of Syn®-Ake reduces the contraction frequency of muscle cells on the face, thereby decreasing expression lines. It prevents the fixation of acetylcholine-the 'contraction messenger' for facial muscles that calms the muscle contractions that would increase wrinkling.

Efficacy Tests - In vivo tests: (people) showed an impressive reduction of 52% in wrinkle size after 28 days. at the recommended concentration of 4%. Achieving a  Botox like effect but without the side effects. 

 

Efficacy Tests- in vitro tests:
The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

SYN®-AKE peptide reduces muscle cell contraction and its action

The smoothing effect (Ra) was measured on 80% of the
volunteers and the anti-wrinkle effect (Rz, Rt) measured  on 73% of the volunteers.

Results showed up to 52% decrease of wrinkle size after 28 days

 

In addition, information from the pharmaceutical company who manufactured and researched   Syn®-Ake have proved it is significantly more powerful than Argireline. 

 Clinical trials were done with 45 subjects for 28 days with twice daily applications. 

Syn®-Ake vs  Argireline and the average smoothing for each group of fifteen subjects was:-

21% for Syn®-Ake vs 4% for Argireline.

The average reduction in wrinkle depth was:-

20% for Syn-Ake vs 2% for Argireline.

The pharmaceutical company that manufacture both actives are now saying that Syn®-Ake is becoming the 21st century antiwrinkle ingredient that surpasses Argireline hands down.  

Syn®-Ake  was better than Argireline in the following:- There were no side effects using Syn®-Ake, and those with very sensitive skin could use this ingredient with no drying effects to the skin.

Syn®-Ake actually kept the skin moist and supple, and decreased wrinkles and lines quicker and better than Argireline. 

Syn®-Ake will certainly become the next super wrinkle reducer for the 21-century and as yet there is nothing else that comes close.

Syn®-Ake-  Is stronger than Vitamin C and works faster than Retinol without the irritating side-effects. 

Syn®-Ake- Increases elastin while repairing the skin, helps smooths lines in the wrinkle prone areas. 

Syn®-Ake- Effective anti wrinkle compound with a snake venom like mode of activity  

Syn®-Ake- Smoothes mimic wrinkles in a short period of time.

 Syn®-Ake- Botox like effect without the side effects, particularly effective against expression lines.

Syn®-Ake- Clinically proven to reduce wrinkles by 52% in 28 days and 82% Smoothing effect giving our clients this effective, painless, Age Killing Ingredient.

Syn®-Ake- Clinically  proven - Syn®-Ake is Significantly more powerful than Argireline:- 

 21% for Syn®-Ake vs. 4% for Argireline.

Syn®-Ake- Suitable for sensitve skin with no drying effects.

 Matrixyl®- Studies Show Matrixyl®- Dramatically Improves Wrinkles

Scientifically Speaking...
Matrixyl®  was discovered through two branches of dermatological research which lead to wrinkle reduction and prevention. These two branches were:
1. What Causes Wrinkles
2. What Can Accelerate the healing of wounds.

You see, a wrinkle is really nothing more than a wound on the skin. Much like a wound caused by a cut or accident, a wrinkle is damage on the skin from outside forces or from the skin's inability to defend itself.

THESE TWO BRANCHES ARE EXACTLY WHAT MATRIXYL® FOCUSES ON. By stimulating the DNA in the lower layers of the skin, your body's natural production of Collagen and Fibroplasts are stimulated intensely to actually trick the body into thinking it is young again. When this happens, the skin will prevent new wrinkles, and powerfully accelerate the healing of the wounds which already exist (your wrinkles).

Over six months, a clinical trial revealed that Matrixyl® temporarily produced “a highly significant reduction in the deep and moderate wrinkles,”. In fact, researchers documented changes as high as 68% (Matrixyl® 1999).
The research left no doubt: Women who had used Matrixyl® throughout the study experienced dramatic results. Further, it was proven that the longer they maintained the use of Matrixyl, the more dramatic their results.

Is Matrixy®l (palmitoyl pentapeptide-3) an effective anti wrinkle product?
Yes. In clinical studies, Matrixyl® was shown to:
increase overall collagen synthesis by up to 117%
increase collagen IV synthesis by up to 327%
increase hyaluronic acid synthesis by up to 267%
Deep wrinkles were reduced by half. Smaller wrinkles and fine lines sometimes faded completely away. And what's even better, every participant in the study showed noticeable improvement within two weeks.

The result was fewer wrinkles and younger-looking skin.
 

Results of a four month French study presented at the 2002 World Congress of Dermatology, revealed an amino-peptide complex known as Matrixyl ® produced dramatic changes in the appearance of aging facial skin.

Changes included:

• 50% decrease in wrinkle depth

• 68% decrease in wrinkle density

• 24% decrease in wrinkle volume

Results of the study demonstrated topical application of non-prescription Matrixyl®  cream improved wrinkle appearance more quickly than retinol without causing irritation and redness. These benefits were confirmed in a separate study that also showed positive changes in elastin and collagen.

Another 12-week study conducted by Proctor & Gamble also showed that non-prescription Matrixyl® offers signinficant benefits for reducing the appearance of fine lines and wrinkles, age spots, and skin firmness.

French Study

The study used profilometry (image analysis of skin) to measure the density, depth and volume of wrinkles around the eyes and consisted of treating the area and monitoring the changes over time. In the first split-face, double-blind trial, 49 women applied the Matrixyl®  cream or a placebo twice daily.

In the active controlled study 16 women compared the effects of cosmetic creams containing Matrixyl®  or retinol 700 ppm on photoaged skin. This trial also used a split-face, double-blind design and included profilometry, echography, and clinical assessments after two and four months of treatment. At two months, Matrixyl®  showed greater improvement than the retinol cream without irritation.

In both trials, the company reports, the findings were statistically significant, saying treatment with the Matrixyl®  cream produced a:

• 50% decrease in wrinkle depth

• 68% decrease in wrinkle density

• 24% decrease in wrinkle volume

Matrixyl®  was also associated with increases in elastin fiber density and thickness and improved regularity of collagen IV, both critical for smooth, supple skin.

Proctor & Gamble Study

92 women, aged 35 to 55 years, with moderate to severe photodamage applied Matrixyl®  in a moisturising base to one side of the face twice daily and placebo to the other side. No other skin care products except for a supplied facial cleanser and a broad spectrum UV sunscreen were allowed.

Changes in fine lines and wrinkles were assessed every four weeks by comparisons of high-resolution digital images. Efficacy was assessed both by digital image analysis and trained graders, and the study participants were also asked to rate effects on their skin appearance.

Improvement in fine lines and wrinkles on the side where Matrixyl ® was applied were noted as early as four weeks.

At the study's end in 12 weeks:

• Wrinkle length was reduced from 170.4 mm at baseline to 147.7 mm

• Participants' subjective ratings indicated significant benefits for improving age spots, dark circles, and skin firmness.

CALMOSENSINE™ is a new product that promotes Well-Being by reducing the perception of unpleasant sensations.  It modulates the perception of temperature, chemical aggressions, and tactile sensation.  By putting the skin at ease, it creates a more comfortable, and relaxed sensation. 

CALMOSENSINE™  contains the first cosmetic active ever shown to reduce the emotional response to tactile aggression, as tested using a Lie Detector to measure the subliminal response to unpleasant sensations.